Publisher Summary This chapter presents a current model for the actions of growth hormone-
releasing hormone (GHRH) in modulating pituitary somatotroph function and provides a
brief overview on the potential involvement of the GHRH signaling system in human
disease. The several steps in the signaling pathway leading to growth hormone (GH)
secretion are subject to disruption, resulting in GH deficiency. As of present, no mutations in
either GHRH or its receptor have been associated with human disease; however, the …