A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
XJ Yang, VV Ogryzko, J Nishikawa, BH Howard… - Nature, 1996 - nature.com
XJ Yang, VV Ogryzko, J Nishikawa, BH Howard, Y Nakatani
Nature, 1996•nature.comThe adenoviral oncoprotein E1A induces progression through the cell cycle by binding to
the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-
associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that
competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle
progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular
interaction between p300/CBP and its associated histone acetylase.
the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-
associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that
competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle
progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular
interaction between p300/CBP and its associated histone acetylase.
Abstract
The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase.
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