Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses

F Sallusto, A Lanzavecchia, CR Mackay - Immunology today, 1998 - cell.com
Immunology today, 1998cell.com
T-cell priming occurs in the lymphoid tissue via T cell–dendritic cell interaction. Conversely,
delayed-type hypersensitivity or allergic reactions can occur in any tissue, following
interaction of T helper 1 (Th1) or Th2 cells with effector leukocytes. Here, Federica Sallusto
and colleagues review the role played by chemokines and chemokine receptors in
positioning T cells for the immune response.
Abstract
T-cell priming occurs in the lymphoid tissue via T cell–dendritic cell interaction. Conversely, delayed-type hypersensitivity or allergic reactions can occur in any tissue, following interaction of T helper 1 (Th1) or Th2 cells with effector leukocytes. Here, Federica Sallusto and colleagues review the role played by chemokines and chemokine receptors in positioning T cells for the immune response.
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