[HTML][HTML] Cardiotrophin-1: biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex
D Pennica, KJ Shaw, TA Swanson, MW Moore… - Journal of Biological …, 1995 - ASBMB
Cardiotrophin-1 (CT-1) is a newly isolated cytokine that was identified based on its ability to
induce cardiac myocyte hypertrophy. It is a member of the family of cytokines that includes
interleukins-6 and− 11, leukemia inhibitory factor (LIF), ciliary neurotrophic factor, and
oncostatin M. These cytokines induce a pleiotropic set of growth and differentiation activities
via receptors that use a common signaling subunit, gp130. In this work we determine the
activity of CT-1 in six in vitro biological assays and examine the composition of its cell …
induce cardiac myocyte hypertrophy. It is a member of the family of cytokines that includes
interleukins-6 and− 11, leukemia inhibitory factor (LIF), ciliary neurotrophic factor, and
oncostatin M. These cytokines induce a pleiotropic set of growth and differentiation activities
via receptors that use a common signaling subunit, gp130. In this work we determine the
activity of CT-1 in six in vitro biological assays and examine the composition of its cell …