Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

M Maffei, J Halaas, E Ravussin, RE Pratley, GH Lee… - Nature medicine, 1995 - nature.com
M Maffei, J Halaas, E Ravussin, RE Pratley, GH Lee, Y Zhang, H Fei, S Kim, R Lallone…
Nature medicine, 1995nature.com
Leptin, the gene product of the obese gene, may play an important role in regulating body
weight by signalling the size of the adipose tissue mass. Plasma leptin was found to be
highly correlated with body mass index (BMI) in rodents and in 87 lean and obese humans.
In humans, there was variability in plasma leptin at each BMI suggesting that there are
differences in its secretion rate from fat. Weight loss due to food restriction was associated
with a decrease in plasma leptin in samples from mice and obese humans.
Abstract
Leptin, the gene product of the obese gene, may play an important role in regulating body weight by signalling the size of the adipose tissue mass. Plasma leptin was found to be highly correlated with body mass index (BMI) in rodents and in 87 lean and obese humans. In humans, there was variability in plasma leptin at each BMI suggesting that there are differences in its secretion rate from fat. Weight loss due to food restriction was associated with a decrease in plasma leptin in samples from mice and obese humans.
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