[HTML][HTML] Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells
Macrophage-colony stimulating factor (M-CSF) contributes to atherogenesis by regulating
macrophage-derived foam cells in atherosclerotic lesions. Here we report that nitric oxide
(NO) inhibits the expression of M-CSF in human vascular endothelial cells independent of
guanylyl cyclase activation. The induction of M-CSF mRNA expression by either oxidized
low density lipoprotein (ox-LDL) or tumor necrosis factor-α (TNFα) was attenuated by NO
donors, S-nitrosoglutathione (GSNO), sodium nitroprusside (SNP), and 3 …
macrophage-derived foam cells in atherosclerotic lesions. Here we report that nitric oxide
(NO) inhibits the expression of M-CSF in human vascular endothelial cells independent of
guanylyl cyclase activation. The induction of M-CSF mRNA expression by either oxidized
low density lipoprotein (ox-LDL) or tumor necrosis factor-α (TNFα) was attenuated by NO
donors, S-nitrosoglutathione (GSNO), sodium nitroprusside (SNP), and 3 …