[HTML][HTML] Recombinant Soluble Trimeric CD40 Ligand Is Biologically Active∗
A Durandy, JF Gauchat, GJ Mazzei… - Journal of Biological …, 1995 - ASBMB
CD40 ligand (CD40L) is expressed on the surface of activated CD4+ T cells, basophils, and
mast cells. Binding of C40L to its receptor, CD40, on the surface of B cells stimulates B cell
proliferation, adhesion and differentiation. A preparation of soluble, recombinant CD40L (Tyr-
45 to Leu-261), containing the full-length 29-kDa protein and two smaller fragments of 18
and 14 kDa, has been shown to induce differentiation of B cells derived either from normal
donors or from patients with X-linked hyper-IgM syndrome (Durandy, A., Schiff, C., Bonnefoy …
mast cells. Binding of C40L to its receptor, CD40, on the surface of B cells stimulates B cell
proliferation, adhesion and differentiation. A preparation of soluble, recombinant CD40L (Tyr-
45 to Leu-261), containing the full-length 29-kDa protein and two smaller fragments of 18
and 14 kDa, has been shown to induce differentiation of B cells derived either from normal
donors or from patients with X-linked hyper-IgM syndrome (Durandy, A., Schiff, C., Bonnefoy …