[HTML][HTML] The zinc finger-containing transcription factors GATA-4,-5, and-6: ubiquitously expressed regulators of tissue-specific gene expression
JD Molkentin - Journal of Biological Chemistry, 2000 - ASBMB
Six GATA transcription factors have been identified in vertebrates, each of which contains a
highly conserved DNA binding domain consisting of two zinc fingers of the motif Cys-X2-Cys-
X17-Cys-X2-Cys (1–9) that directs binding to the nucleotide sequence element (A/T) GATA
(A/G)(10, 11). Based on their expression patterns, the GATA proteins have been divided into
two subfamilies, GATA-1,-2, and-3 and GATA-4,-5, and-6. GATA-1,-2, and-3 genes are
prominently expressed in hematopoietic stem cells where they regulate differentiation …
highly conserved DNA binding domain consisting of two zinc fingers of the motif Cys-X2-Cys-
X17-Cys-X2-Cys (1–9) that directs binding to the nucleotide sequence element (A/T) GATA
(A/G)(10, 11). Based on their expression patterns, the GATA proteins have been divided into
two subfamilies, GATA-1,-2, and-3 and GATA-4,-5, and-6. GATA-1,-2, and-3 genes are
prominently expressed in hematopoietic stem cells where they regulate differentiation …