[HTML][HTML] A mitogenic action for fibrinogen mediated through intercellular adhesion molecule-1
EE Gardiner, SE D'Souza - Journal of Biological Chemistry, 1997 - ASBMB
Intercellular adhesion molecule-1 (ICAM-1) is a cell surface ligand for α L β 2 and α M β 2
integrins and has a key role in leukocyte adhesion to the vascular endothelium. The plasma
protein fibrinogen has also been shown to interact with ICAM-1. We have investigated the
effect of fibrinogen binding to ICAM-1-expressing cells on cell proliferation. The inclusion of
200–800 nmfibrinogen but not fibronectin to the culture medium of Raji induced a 2–4-fold
increase in [3 H] thymidine incorporation after 8 h. Cell proliferation in cultures containing …
integrins and has a key role in leukocyte adhesion to the vascular endothelium. The plasma
protein fibrinogen has also been shown to interact with ICAM-1. We have investigated the
effect of fibrinogen binding to ICAM-1-expressing cells on cell proliferation. The inclusion of
200–800 nmfibrinogen but not fibronectin to the culture medium of Raji induced a 2–4-fold
increase in [3 H] thymidine incorporation after 8 h. Cell proliferation in cultures containing …