Treatment of murine lupus with CTLA4Ig

BK Finck, PS Linsley, D Wofsy - Science, 1994 - science.org
BK Finck, PS Linsley, D Wofsy
Science, 1994science.org
The interaction of B7-related molecules on antigen-presenting cells with CD28 or CTLA-4
antigens on T cells provides a second signal for T cell activation. Selective inhibition of the
B7-CD28 or B7-CTLA-4 interactions produces antigen-specific T cell unresponsiveness in
vitro and suppresses immune function in vivo. To determine whether selective inhibition of
the B7-CD28 or B7-CTLA-4 interactions could suppress spontaneous autoimmune disease,
a B7-binding protein was generated by genetic fusion of the extracellular domain of murine …
The interaction of B7-related molecules on antigen-presenting cells with CD28 or CTLA-4 antigens on T cells provides a second signal for T cell activation. Selective inhibition of the B7-CD28 or B7-CTLA-4 interactions produces antigen-specific T cell unresponsiveness in vitro and suppresses immune function in vivo. To determine whether selective inhibition of the B7-CD28 or B7-CTLA-4 interactions could suppress spontaneous autoimmune disease, a B7-binding protein was generated by genetic fusion of the extracellular domain of murine CTLA-4 to the Fc portion of a mouse immunoglobulin G2a monoclonal antibody (muCTLA4Ig). In lupus-prone NZB/NZW filial generation (F1) mice, treatment with muCTLA4Ig blocked autoantibody production and prolonged life, even when treatment was delayed until the most advanced stage of clinical illness. These findings suggest a possible role for human CTLA4Ig in the treatment of autoimmune diseases in humans.
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