Publisher Summary Nitric oxide (NO) is known to bind tightly to the heme iron of hemoglobin
(Hb). Innumerable physiological and path physiological roles for NO raised new questions
relevant to the functional behavior of Hb. This chapter discusses various schemes for the
synthesis of S-nitrosohemoglobin (SNO)-oxyHb, SNO-deoxyHb, and SNO-metHb. The
chapter discusses the basic biochemical properties of these molecules and their roles in
physiology. S-nitrosodeoxyhemoglobin (SNO-deoxyHb) is synthesized in an anaerobic …