Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products.
LK Ernst, JG van de Winkel, IM Chiu… - Journal of Biological …, 1992 - ASBMB
Three distinct but closely related classes of receptors that bind the Fc portion of
immunoglobulin G (Fc gamma RI,-II, and-III) have been identified in humans. Only Fc
gamma RI has high affinity for ligand and has a unique third extracellular domain (EC3). We
have characterized three genes for human Fc gamma RI (A, B, and C). Each gene consists
of six exons, spans 9.4 kilobase pairs, and localizes to chromosome 1. Although they are
remarkably similar, genes B and C are notably different from A; in-frame stop codons are …
immunoglobulin G (Fc gamma RI,-II, and-III) have been identified in humans. Only Fc
gamma RI has high affinity for ligand and has a unique third extracellular domain (EC3). We
have characterized three genes for human Fc gamma RI (A, B, and C). Each gene consists
of six exons, spans 9.4 kilobase pairs, and localizes to chromosome 1. Although they are
remarkably similar, genes B and C are notably different from A; in-frame stop codons are …