Inhaled glucocorticoid therapy of childhood asthma is associated with reduced peripheral blood T cell activation and 'Th2-type'cytokine mRNA expression
V Gemou-Engesaeth, A Bush, AB Kay, Q Hamid… - …, 1997 - publications.aap.org
Objective. To investigate the role of activated T cells and their cytokine products in the
pathogenesis of childhood asthma. Methods. PBMC were obtained from 17 symptomatic
asthmatic children (age 7 to 15 yr) and 7 nonasthmatic controls matched for age and atopic
status. Asthmatics were placed in 2 groups with initial prebronchodilator FEV1< 75%(Group
I, n= 9) or≥ 75%(Group II, n= 8) predicted. Expression of activation markers on peripheral
blood T cells (asthmatics), and expression of cytokine mRNA (asthmatics and controls) were …
pathogenesis of childhood asthma. Methods. PBMC were obtained from 17 symptomatic
asthmatic children (age 7 to 15 yr) and 7 nonasthmatic controls matched for age and atopic
status. Asthmatics were placed in 2 groups with initial prebronchodilator FEV1< 75%(Group
I, n= 9) or≥ 75%(Group II, n= 8) predicted. Expression of activation markers on peripheral
blood T cells (asthmatics), and expression of cytokine mRNA (asthmatics and controls) were …