Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia.

AJ Coyle, F Erard, C Bertrand, S Walti… - The Journal of …, 1995 - rupress.org
AJ Coyle, F Erard, C Bertrand, S Walti, H Pircher, G Le Gros
The Journal of experimental medicine, 1995rupress.org
Virus infections of the lung are thought to predispose individuals to asthma, a disease
characterized by eosinophil infiltration of the airways. CD8+ T cells are an important part of
the host response to virus infection, however, they have no reported role in eosinophil
recruitment. We developed a mouse model of virus peptide-stimulated CD8+ T cell immune
responses in the lung. We found that bystander CD4+ T helper cell type 2 immune
responses to ovalbumin switched the virus peptide-specific CD8+ T cells in the lung to …
Virus infections of the lung are thought to predispose individuals to asthma, a disease characterized by eosinophil infiltration of the airways. CD8+ T cells are an important part of the host response to virus infection, however, they have no reported role in eosinophil recruitment. We developed a mouse model of virus peptide-stimulated CD8+ T cell immune responses in the lung. We found that bystander CD4+ T helper cell type 2 immune responses to ovalbumin switched the virus peptide-specific CD8+ T cells in the lung to interleukin (IL) 5 production. Furthermore, when such IL-5-producing CD8 T cells were challenged via the airways with virus peptide, a significant eosinophil infiltration was induced. In vitro studies indicated that IL-4 could switch the virus-specific CD8+ T cells to IL-5 production. These results could explain the link between virus infection and acute exacerbation of asthma and, perhaps more importantly, they indicate an IL-4-dependent mechanism that would impair CD8+ T cell responses and delay viral clearance from the host.
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