Immunopathological mechanisms in respiratory syncytial virus disease
PJM Openshaw - Springer seminars in immunopathology, 1995 - Springer
Springer seminars in immunopathology, 1995•Springer
Conclusions The potential roles of different components of the immune response to RSV are
summarised in Table 4. In my view, the evidence favours a dominant role for T cells in
causing bronchiolitis and disease augmentation by vaccines. The different roles of various T
cell subsets are strikingly illustrated by the mouse model, although the results from mouse
studies should not be interpreted too literally in relation to human disease. Animal models
are pivotal in suggesting studies that should be performed in man. It is hoped that current …
summarised in Table 4. In my view, the evidence favours a dominant role for T cells in
causing bronchiolitis and disease augmentation by vaccines. The different roles of various T
cell subsets are strikingly illustrated by the mouse model, although the results from mouse
studies should not be interpreted too literally in relation to human disease. Animal models
are pivotal in suggesting studies that should be performed in man. It is hoped that current …
Conclusions
The potential roles of different components of the immune response to RSV are summarised in Table 4. In my view, the evidence favours a dominant role for T cells in causing bronchiolitis and disease augmentation by vaccines. The different roles of various T cell subsets are strikingly illustrated by the mouse model, although the results from mouse studies should not be interpreted too literally in relation to human disease. Animal models are pivotal in suggesting studies that should be performed in man. It is hoped that current advances in understanding disease-enhancing immune responses to RSV will result in new clinical approaches to prevention and treatment.
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