Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study

TR O'Brien, WA Blattner, D Waters, ME Eyster… - Jama, 1996 - jamanetwork.com
Objective.—To determine if the long-term incidence of the acquired immunodeficiency
syndrome (AIDS) is related to human immunodeficiency virus type 1 (HIV-1) RNA levels
measured early in HIV-1 infection. Design.—Epidemiologic cohort study. Setting.—Five
hemophilia treatment centers in the United States. Subjects.—A total of 165 subjects with
hemophilia and HIV-1 infection (age at HIV-1 seroconversion, 1-66 years) followed from
1979 to 1995. Methods.—The HIV-1 RNA level was measured by polymerase chain reaction …