Induction of the proto-oncogene c-jun by angiotensin II
AJ Naftilan, GK Gilliland, CS Eldridge… - Molecular and cellular …, 1990 - Am Soc Microbiol
AJ Naftilan, GK Gilliland, CS Eldridge, AS Kraft
Molecular and cellular biology, 1990•Am Soc MicrobiolAngiotensin (Ang) II causes hypertrophy of rat aortic smooth muscle cells in culture and
results in the rapid activation of c-fos. This study demonstrated that Ang II also activated c-
jun and, in addition, could activate the AP-1 enhancer element. These data add support for a
role of Ang II as an important mediator of vascular smooth muscle cell growth.
results in the rapid activation of c-fos. This study demonstrated that Ang II also activated c-
jun and, in addition, could activate the AP-1 enhancer element. These data add support for a
role of Ang II as an important mediator of vascular smooth muscle cell growth.
Abstract
Angiotensin (Ang) II causes hypertrophy of rat aortic smooth muscle cells in culture and results in the rapid activation of c-fos. This study demonstrated that Ang II also activated c-jun and, in addition, could activate the AP-1 enhancer element. These data add support for a role of Ang II as an important mediator of vascular smooth muscle cell growth.
American Society for Microbiology