Rhesus monkeys that were maintained on a diet containing low, yet adequate, amounts of
vitamins C and E and in which linoleate and linolenate represented 1.4% and 0.08% of the
total caloric intake, respectively, developed liver fibrosis after consuming alcohol (mean, 2.6
g kg-1 d-1) over a period of 3 years. In the liver, several polyunsaturated fatty acids including
18: 2n6, 20: 4n6, and 22: 6n3 decreased compared with dietary controls, and similar
findings were also observed in plasma lipoproteins and erythrocytes. The amount of alcohol …