Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology
H Rouach, V Fataccioli, M Gentil, SW French… - Hepatology, 1997 - journals.lww.com
Liver lipid peroxidation, nonheme iron, antioxidants, and protein oxidation were investigated
in experimental alcohol–induced liver disease in the rat. Wistar male rats were
intragastrically and continuously infused for 4 weeks with a high–fat diet plus an ethanol or
an isocaloric amount of dextrose, maintaining a high blood alcohol level (200–300 mg%).
This model induced fatty liver, spotty necrosis, and focal inflammation. This pathology was
associated with an enhanced lipid peroxidation and a decrease in the major antioxidant …
in experimental alcohol–induced liver disease in the rat. Wistar male rats were
intragastrically and continuously infused for 4 weeks with a high–fat diet plus an ethanol or
an isocaloric amount of dextrose, maintaining a high blood alcohol level (200–300 mg%).
This model induced fatty liver, spotty necrosis, and focal inflammation. This pathology was
associated with an enhanced lipid peroxidation and a decrease in the major antioxidant …