[HTML][HTML] Identification of the major urinary metabolite of the F2-isoprostane 8-iso-prostaglandin F2α in humans
LJ Roberts, KP Moore, WE Zackert, JA Oates… - Journal of Biological …, 1996 - ASBMB
F 2-isoprostanes are prostaglandin-like products of nonenzymatic lipid peroxidation.
Measurement of levels of endogenous unmetabolized F 2-isoprostanes has proven to be a
valuable approach to assess oxidative stress in vivo. However, measurement of levels of
urinary metabolites of F 2-isoprostanes in timed urine collections offers an advantage over
measuring unmetabolized F 2-isoprostanes, eg in a plasma sample, in that it can provide an
integrated index of isoprostane production over time. Therefore, we sought to identify the …
Measurement of levels of endogenous unmetabolized F 2-isoprostanes has proven to be a
valuable approach to assess oxidative stress in vivo. However, measurement of levels of
urinary metabolites of F 2-isoprostanes in timed urine collections offers an advantage over
measuring unmetabolized F 2-isoprostanes, eg in a plasma sample, in that it can provide an
integrated index of isoprostane production over time. Therefore, we sought to identify the …