IL-12 deaths: explanation and a puzzle
J Cohen - Science, 1995 - science.org
Science, 1995•science.org
Researchers investigating toxic reactions that killed two patients in a trial of interleukin-12
earlier this year have reached a surprising conclusion: The drug is highly toxic if it is given in
multiple high doses, but those effects can be avoided if the multiple doses are preceded by a
single dose followed by a rest period. The initial dose apparently imprints a memory on the
immune system, but the mechanism is unclear.
earlier this year have reached a surprising conclusion: The drug is highly toxic if it is given in
multiple high doses, but those effects can be avoided if the multiple doses are preceded by a
single dose followed by a rest period. The initial dose apparently imprints a memory on the
immune system, but the mechanism is unclear.
Researchers investigating toxic reactions that killed two patients in a trial of interleukin-12 earlier this year have reached a surprising conclusion: The drug is highly toxic if it is given in multiple high doses, but those effects can be avoided if the multiple doses are preceded by a single dose followed by a rest period. The initial dose apparently imprints a memory on the immune system, but the mechanism is unclear.
AAAS