Regulation of human IL-18 mRNA expression

JD Marshall, M Aste-Amézaga, SS Chehimi… - Clinical …, 1999 - Elsevier
As virtually nothing is known about the pattern of expression of human IL-18, we
investigated certain factors that may contribute to the regulation of IL-18 mRNA
accumulation and compared this with regulation of the human gene encoding the p40 chain
of IL-12, a cytokine that shares similar biologic activity with IL-18. IL-18 mRNA was
expressed constitutively in unstimulated PBMC or monocytes, unlike p40, which required
induction by a stimulus. Upon stimulation, IL-18 transcript accumulation was enhanced with …