[HTML][HTML] IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB
Immunity, 1997•cell.com
In these studies, IFNγ-inducing factor (IGIF), unlike IL-12, did not drive Th1 development in
BALB/c or C57BL/6 mice, but like IL-1α, potentiated IL-12–driven Th1 development in
BALB/c mice. IGIF and IL-12 synergized for IFNγ production from Th1 cells. Unlike IL-1α, IGIF
had no effect on Th2 cells. IGIF signaled through IRAK, IL-1 receptor–associated kinase, to
induce nuclear translocation of p65/p50 NFκB in Th1 cells. IL-1α had no effect on
proliferation, cytokine production, or NFκB activation in Th1 cells but activated NFκB and …
BALB/c or C57BL/6 mice, but like IL-1α, potentiated IL-12–driven Th1 development in
BALB/c mice. IGIF and IL-12 synergized for IFNγ production from Th1 cells. Unlike IL-1α, IGIF
had no effect on Th2 cells. IGIF signaled through IRAK, IL-1 receptor–associated kinase, to
induce nuclear translocation of p65/p50 NFκB in Th1 cells. IL-1α had no effect on
proliferation, cytokine production, or NFκB activation in Th1 cells but activated NFκB and …
Abstract
In these studies, IFNγ-inducing factor (IGIF), unlike IL-12, did not drive Th1 development in BALB/c or C57BL/6 mice, but like IL-1α, potentiated IL-12–driven Th1 development in BALB/c mice. IGIF and IL-12 synergized for IFNγ production from Th1 cells. Unlike IL-1α, IGIF had no effect on Th2 cells. IGIF signaled through IRAK, IL-1 receptor–associated kinase, to induce nuclear translocation of p65/p50 NFκB in Th1 cells. IL-1α had no effect on proliferation, cytokine production, or NFκB activation in Th1 cells but activated NFκB and proliferation in Th2 cells. Thus, Th1 and Th2 cells may differ in responsiveness and receptor expression for IL-1 family molecules. IGIF and IL-1α may differentially amplify Th1 and Th2 effector responses, respectively.
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