Mechanism of activation and function of protein kinase B
The past year has seen significant advances in our understanding of how protein kinase B
(PKB) is activated and of the central role it plays in insulin signalling and in mediating the
protective effects of survival factors against apoptosis. The highlights include the discovery
of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the
identification of several physiological substrates for PKB.
(PKB) is activated and of the central role it plays in insulin signalling and in mediating the
protective effects of survival factors against apoptosis. The highlights include the discovery
of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the
identification of several physiological substrates for PKB.
The past year has seen significant advances in our understanding of how protein kinase B (PKB) is activated and of the central role it plays in insulin signalling and in mediating the protective effects of survival factors against apoptosis. The highlights include the discovery of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the identification of several physiological substrates for PKB.
Elsevier