[HTML][HTML] Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes
JF Tanti, T Grémeaux, S Grillo, V Calleja… - Journal of Biological …, 1996 - ASBMB
Insulin stimulates glucose transport in its target cells by recruiting the glucose transporter
Glut 4 from an intracellular compartment to the cell surface. Previous studies have indicated
that phosphatidylinositol 3-kinase (PI 3-kinase) is a necessary step in this insulin action. We
have investigated whether PI 3-kinase activation is sufficient to promote Glut 4 translocation
in transiently transfected adipocytes. Rat adipose cells were cotransfected with expression
vectors that allowed transient expression of epitope-tagged Glut 4 and a constitutively active …
Glut 4 from an intracellular compartment to the cell surface. Previous studies have indicated
that phosphatidylinositol 3-kinase (PI 3-kinase) is a necessary step in this insulin action. We
have investigated whether PI 3-kinase activation is sufficient to promote Glut 4 translocation
in transiently transfected adipocytes. Rat adipose cells were cotransfected with expression
vectors that allowed transient expression of epitope-tagged Glut 4 and a constitutively active …