Continuous administration of insulin-like growth factor-I and basic fibroblast growth factor does not affect left ventricular geometry after acute myocardial infarction in …
M Scheinowitz, D Abramov, A Kotlyar, N Savion… - International journal of …, 1998 - Elsevier
M Scheinowitz, D Abramov, A Kotlyar, N Savion, M Eldar
International journal of cardiology, 1998•ElsevierWe examined the long-term effect of exogenous administration of bFGF and IGF-I on
myocardial geometry in 72 Sprague–Dawley male rats subjected to AMI. A preloaded
miniature osmotic pump subsequently implanted in the peritoneum for continuous infusion
(1 week) of IGF-I, bFGF, IGF-I+ bFGF or rat albumin. Six weeks following AMI the rats were
killed and cross-section slices were analyzed for left ventricular geometry. No differences
were observed between IGF-I-treated, bFGF-treated, IGF-I+ bFGF-treated and control groups …
myocardial geometry in 72 Sprague–Dawley male rats subjected to AMI. A preloaded
miniature osmotic pump subsequently implanted in the peritoneum for continuous infusion
(1 week) of IGF-I, bFGF, IGF-I+ bFGF or rat albumin. Six weeks following AMI the rats were
killed and cross-section slices were analyzed for left ventricular geometry. No differences
were observed between IGF-I-treated, bFGF-treated, IGF-I+ bFGF-treated and control groups …
We examined the long-term effect of exogenous administration of bFGF and IGF-I on myocardial geometry in 72 Sprague–Dawley male rats subjected to AMI. A preloaded miniature osmotic pump subsequently implanted in the peritoneum for continuous infusion (1 week) of IGF-I, bFGF, IGF-I+bFGF or rat albumin. Six weeks following AMI the rats were killed and cross-section slices were analyzed for left ventricular geometry. No differences were observed between IGF-I-treated, bFGF-treated, IGF-I+bFGF-treated and control groups in all parameters of the left ventricle.
Elsevier