[HTML][HTML] Membrane-permeant esters of phosphatidylinositol 3, 4, 5-trisphosphate
T Jiang, G Sweeney, MT Rudolf, A Klip… - Journal of Biological …, 1998 - ASBMB
Phosphoinositide 3-OH kinases and their products, D-3 phosphorylated phosphoinositides,
are increasingly recognized as crucial elements in many signaling cascades. A reliable
means to introduce these lipids into intact cells would be of great value for showing the
physiological roles of this pathway and for testing the specificity of pharmacological
inhibitors of the kinases. We have stereospecifically synthesized di-C 8-PIP 3/AM and di-C
12-PIP 3/AM, the heptakis (acetoxymethyl) esters of dioctanoyl-and …
are increasingly recognized as crucial elements in many signaling cascades. A reliable
means to introduce these lipids into intact cells would be of great value for showing the
physiological roles of this pathway and for testing the specificity of pharmacological
inhibitors of the kinases. We have stereospecifically synthesized di-C 8-PIP 3/AM and di-C
12-PIP 3/AM, the heptakis (acetoxymethyl) esters of dioctanoyl-and …