Co-receptors for HIV-1 entry
JP Moore, A Trkola, T Dragic - Current opinion in immunology, 1997 - Elsevier
JP Moore, A Trkola, T Dragic
Current opinion in immunology, 1997•ElsevierHIV-1 enters its target cells by fusion at the plasma membrane. The primary cellular receptor
for HIV is CD4, but this molecule is insufficient to permit viral fusion. During 1996, the
necessary entry co-factors (co-receptors or second receptors) were identified as being
members of the seven-transmembrane-spanning receptor family fusin: CXCR4 for T-tropic
strains and CCR5, principally, for M-tropic strains. The co-receptor functions of these
proteins are inhibited by their natural α-and β-chemokine ligands.
for HIV is CD4, but this molecule is insufficient to permit viral fusion. During 1996, the
necessary entry co-factors (co-receptors or second receptors) were identified as being
members of the seven-transmembrane-spanning receptor family fusin: CXCR4 for T-tropic
strains and CCR5, principally, for M-tropic strains. The co-receptor functions of these
proteins are inhibited by their natural α-and β-chemokine ligands.
HIV-1 enters its target cells by fusion at the plasma membrane. The primary cellular receptor for HIV is CD4, but this molecule is insufficient to permit viral fusion. During 1996, the necessary entry co-factors (co-receptors or second receptors) were identified as being members of the seven-transmembrane-spanning receptor family fusin: CXCR4 for T-tropic strains and CCR5, principally, for M-tropic strains. The co-receptor functions of these proteins are inhibited by their natural α- and β-chemokine ligands.
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