[HTML][HTML] Identification of a domain in the Angiotensin II Type 1 receptor determining Gq coupling by the use of receptor chimeras (∗)

C Wang, S Jayadev, JA Escobedo - Journal of Biological Chemistry, 1995 - ASBMB
The angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors belong to the seven
transmembrane receptor superfamily. Previous studies have suggested that the AT1R
couples to a G q signaling pathway, whereas the AT2R does not associate with G q. To
identify the role that individual intracellular domains play in AT1R function, AT1R/AT2R
chimeric receptors were prepared by substitution of intracellular loops. CHO cells
expressing these chimeras were used to test angiotensin II-induced c-fos expression and Ca …