Homeostasis and self-tolerance in the immune system: turning lymphocytes off
LV Parijs, AK Abbas - Science, 1998 - science.org
LV Parijs, AK Abbas
Science, 1998•science.orgThe immune system responds in a regulated fashion to microbes and eliminates them, but it
does not respond to self-antigens. Several regulatory mechanisms function to terminate
responses to foreign antigens, returning the immune system to a basal state after the antigen
has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here,
recent advances in understanding of the molecular bases and physiologic roles of the
mechanisms of immune homeostasis are examined.
does not respond to self-antigens. Several regulatory mechanisms function to terminate
responses to foreign antigens, returning the immune system to a basal state after the antigen
has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here,
recent advances in understanding of the molecular bases and physiologic roles of the
mechanisms of immune homeostasis are examined.
The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.
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