[HTML][HTML] Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress: inhibition of c-Jun N-terminal kinase activity and AP-1 …
Y Liu, M Gorospe, C Yang, NJ Holbrook - Journal of Biological Chemistry, 1995 - ASBMB
Irradiation of mammalian cells with short wavelength ultraviolet light (UVC) evokes a
cascade of phosphorylation events leading to altered gene expression. Both the classic
mitogen-activated protein (MAP) kinases and the distantly related c-Jun N-terminal kinases
(JNK) contribute to the response via phosphorylation of transcription factors including AP-1.
These kinases are themselves regulated via reversible phosphorylation, and several
recently identified specific MAP kinase phosphatases (MKP) have been implicated in down …
cascade of phosphorylation events leading to altered gene expression. Both the classic
mitogen-activated protein (MAP) kinases and the distantly related c-Jun N-terminal kinases
(JNK) contribute to the response via phosphorylation of transcription factors including AP-1.
These kinases are themselves regulated via reversible phosphorylation, and several
recently identified specific MAP kinase phosphatases (MKP) have been implicated in down …