Southwestern internal medicine conference: hypertrophic cardiomyopathy: current views on etiology, pathophysiology, and management
JWR Lawson - The American journal of the medical sciences, 1987 - Elsevier
Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease of unknown cause that
is characterized by a hypertrophied, nondilated, hypercontractile left ventricle. Its etiology
and pathogenesis remain undefined but the three principal factors implicated are a genetic
predisposition, a hypersensitivity to catecholamines, and an abnormal calcium metabolism.
The hypertrophy typically involves the intraventricular septum to varying degrees, but may
also involve the apex or free wall and even be concentric. The disease occurs in either an …
is characterized by a hypertrophied, nondilated, hypercontractile left ventricle. Its etiology
and pathogenesis remain undefined but the three principal factors implicated are a genetic
predisposition, a hypersensitivity to catecholamines, and an abnormal calcium metabolism.
The hypertrophy typically involves the intraventricular septum to varying degrees, but may
also involve the apex or free wall and even be concentric. The disease occurs in either an …