Cryptic chemotactic activity of fibronectin for human monocytes resides in the 120-kDa fibroblastic cell-binding fragment.
RA Clark, NE Wikner, DE Doherty, DA Norris - Journal of Biological …, 1988 - ASBMB
Monocytes and lymphocytes form a second wave of infiltrating blood leukocytes in areas of
tissue injury. The mechanisms for monocyte accumulation at these sites are not completely
understood. Recently, however, fragments from extracellular matrix proteins including
collagen, elastin, and fibronectin have been shown to induce monocyte chemotaxis. In this
report we demonstrate that chemotactic activity for human monocytes is expressed when a
120-kDa fragment containing the RGDS cell-binding peptide is released from intact …
tissue injury. The mechanisms for monocyte accumulation at these sites are not completely
understood. Recently, however, fragments from extracellular matrix proteins including
collagen, elastin, and fibronectin have been shown to induce monocyte chemotaxis. In this
report we demonstrate that chemotactic activity for human monocytes is expressed when a
120-kDa fragment containing the RGDS cell-binding peptide is released from intact …