[HTML][HTML] The MEKK-JNK pathway is stimulated by α1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy
MT Ramirez, VP Sah, XL Zhao, JJ Hunter… - Journal of Biological …, 1997 - ASBMB
In neonatal rat ventricular myocytes, stimulation of the α 1-adrenergic receptor (α 1-AdrR)
activates a program of genetic and morphological changes characterized by transcriptional
activation of the atrial natriuretic factor (ANF) gene and enlargement (hypertrophy) of the
cells. The low molecular weight GTPase Ras has been established as an important
regulator of hypertrophy bothin vitro and in vivo. Ras activates a kinase cascade involving
Raf, the mitogen-activated protein kinase kinase (MEK), and the extracellular signal …
activates a program of genetic and morphological changes characterized by transcriptional
activation of the atrial natriuretic factor (ANF) gene and enlargement (hypertrophy) of the
cells. The low molecular weight GTPase Ras has been established as an important
regulator of hypertrophy bothin vitro and in vivo. Ras activates a kinase cascade involving
Raf, the mitogen-activated protein kinase kinase (MEK), and the extracellular signal …