The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion
CM Pombo, JV Bonventre, J Avruch… - Journal of Biological …, 1994 - ASBMB
The signal transduction pathways that mediate activation of trans acting factors controlling
an organ's response to ischemia are unknown. The stress-activated protein kinases
(SAPKs), a subfamily of the extracellular signal-regulated kinases (ERKs), phosphorylate c-
Jun within the amino-terminal transactivation domain and are activated in response to a
variety of cellular stresses. We determined whether SAPKs are activated in response to
ischemia, an extreme, albeit common, pathophysiologic stress. Rats underwent 40 min of …
an organ's response to ischemia are unknown. The stress-activated protein kinases
(SAPKs), a subfamily of the extracellular signal-regulated kinases (ERKs), phosphorylate c-
Jun within the amino-terminal transactivation domain and are activated in response to a
variety of cellular stresses. We determined whether SAPKs are activated in response to
ischemia, an extreme, albeit common, pathophysiologic stress. Rats underwent 40 min of …