Protease-inhibitor deficiencies in a patient with Weber-Christian panniculitis
E Bleumink, HA Klokke - Archives of dermatology, 1984 - jamanetwork.com
• The diagnosis of Weber-Christian disease was made by clinical and histopathologic
findings in a 25-year-old woman who had recurrent nodules on the legs and arms. The
patient's history also disclosed multiple episodes of swelling from trauma. Histopathologic
examination of the lesions showed a prominent vasculitis. Studies of serum complement and
kallikrein levels and of the fibrinolysisclotting system showed a decrease in the levels of C3,
C4, and total hemolytic complement activity and deficiencies (< 20% of the normal values) of …
findings in a 25-year-old woman who had recurrent nodules on the legs and arms. The
patient's history also disclosed multiple episodes of swelling from trauma. Histopathologic
examination of the lesions showed a prominent vasculitis. Studies of serum complement and
kallikrein levels and of the fibrinolysisclotting system showed a decrease in the levels of C3,
C4, and total hemolytic complement activity and deficiencies (< 20% of the normal values) of …