[HTML][HTML] Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3-or anti-CD45-stimulated T cells
HL Ostergaard, O Lou, CW Arendt, NN Berg - Journal of Biological …, 1998 - ASBMB
Antibodies to either CD3 or CD45 have been shown to induce dramatic changes in cell
morphology, increased tyrosine phosphorylation of cellular proteins, and the association of a
subset of these proteins with the tyrosine kinase Lck. The current study was initiated to
determine the identity of the tyrosine-phosphorylated 70–80 kDa protein that becomes Lck-
associated after stimulation with anti-CD45 or anti-CD3. We demonstrate that the
cytoskeletal protein paxillin becomes tyrosine-phosphorylated when cells are plated on …
morphology, increased tyrosine phosphorylation of cellular proteins, and the association of a
subset of these proteins with the tyrosine kinase Lck. The current study was initiated to
determine the identity of the tyrosine-phosphorylated 70–80 kDa protein that becomes Lck-
associated after stimulation with anti-CD45 or anti-CD3. We demonstrate that the
cytoskeletal protein paxillin becomes tyrosine-phosphorylated when cells are plated on …