[HTML][HTML] Differential regulation of Pyk2 and focal adhesion kinase (FAK): the C-terminal domain of FAK confers response to cell adhesion

C Zheng, Z Xing, ZC Bian, C Guo, A Akbay… - Journal of Biological …, 1998 - ASBMB
Pyk2 is a recently described cytoplasmic tyrosine kinase that is related to focal adhesion
kinase (FAK) and can be activated by a variety of stimuli that elevate intracellular calcium. In
this report, we showed that Pyk2 and FAK tyrosine phosphorylation are regulated
differentially by integrin-mediated cell adhesion and soluble factors both in rat aortic smooth
muscle cells, which express endogenous Pyk2 and FAK, and in transfected Chinese
hamster ovary cells. We also found that Pyk2 is diffusely present throughout the cytoplasm …