[HTML][HTML] Differential signaling by the focal adhesion kinase and cell adhesion kinase β
MD Schaller, T Sasaki - Journal of Biological Chemistry, 1997 - ASBMB
pp125 FAK and CAKβ/Pyk2/CadTK/RAFTK are related protein-tyrosine kinases. It is
therefore of interest whether CAKβ shares some of the properties of pp125 FAK. Using
recombinant glutathioneS-transferase fusion proteins, we show that the C-terminal domains
of both proteins bind paxillin in vitro. The C-terminal domain of CAKβ was engineered to be
autonomously expressed in chicken embryo cells and, like pp125 FAK and p41/43 FRNK
(the C-terminal noncatalytic domain of pp125 FAK), was found to localize to cellular focal …
therefore of interest whether CAKβ shares some of the properties of pp125 FAK. Using
recombinant glutathioneS-transferase fusion proteins, we show that the C-terminal domains
of both proteins bind paxillin in vitro. The C-terminal domain of CAKβ was engineered to be
autonomously expressed in chicken embryo cells and, like pp125 FAK and p41/43 FRNK
(the C-terminal noncatalytic domain of pp125 FAK), was found to localize to cellular focal …