Mast cells and leukotrienes mediate neutrophil sequestration and lung edema after remote ischemia in rodents
G Goldman, R Welbourn, JM Klausner, L Kobzik… - Surgery, 1992 - surgjournal.com
Reperfusion of ischemic hindlimbs leads to leukotriene B 4 (LTB 4) and polymorphonuclear
neutrophil (PMN)-dependent lung injury. Pulmonary mast cells are capable of synthesizing
LTB 4 and are potential mediators of this inflammatory response. This study tests their role in
PMN sequestration and pulmonary edema after hindlimb ischemia. Anesthetized, mast cell-
sufficient mice (n= 8) or their congeneic mast cell-deficient strain (n= 8) were subjected to 3
hours of hindlimb ischemia. After another 3 hours of reperfusion, plasma LTB 4 levels rose to …
neutrophil (PMN)-dependent lung injury. Pulmonary mast cells are capable of synthesizing
LTB 4 and are potential mediators of this inflammatory response. This study tests their role in
PMN sequestration and pulmonary edema after hindlimb ischemia. Anesthetized, mast cell-
sufficient mice (n= 8) or their congeneic mast cell-deficient strain (n= 8) were subjected to 3
hours of hindlimb ischemia. After another 3 hours of reperfusion, plasma LTB 4 levels rose to …