Permanent defects in rat peripheral auditory function following perinatal hypothyroidism: determination of a critical period
R Hébert, JM Langlois, JH Dussault - Developmental Brain Research, 1985 - Elsevier
Rats were treated with propylthiouracil (PTU) for 10-day periods beginning at different ages.
Daily injections of l-thyroxine (T 4) were administered concurrently with PTU to a group of
rats which served as one control group. Peripheral auditory function was evaluated by the
brainstem response audiometry (BSRA) technique performed at 12, 16, 25 and 120 days of
age. PTU treatment significantly increased wave I latency (cochlear nerve compound action
potential) in adult rats when administered from 3 days before delivery through 6 days of age …
Daily injections of l-thyroxine (T 4) were administered concurrently with PTU to a group of
rats which served as one control group. Peripheral auditory function was evaluated by the
brainstem response audiometry (BSRA) technique performed at 12, 16, 25 and 120 days of
age. PTU treatment significantly increased wave I latency (cochlear nerve compound action
potential) in adult rats when administered from 3 days before delivery through 6 days of age …