[HTML][HTML] Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain
AN Hollenberg, T Monden, JP Madura, K Lee… - Journal of Biological …, 1996 - ASBMB
Recently, a family of nuclear co-repressor proteins (TRACs) have been identified that
interact with thyroid hormone (TR) and retinoic acid receptors to mediate ligand-
independent repression of gene transcription. In this report, we have cloned and
characterized a human TRAC, which when expressed as a truncated protein lacking its
repressing domains, can abolish endogenous cellular TRAC activity. Use of this inhibitor
has uncovered a differential function of TRACs on negative versus positive thyroid hormone …
interact with thyroid hormone (TR) and retinoic acid receptors to mediate ligand-
independent repression of gene transcription. In this report, we have cloned and
characterized a human TRAC, which when expressed as a truncated protein lacking its
repressing domains, can abolish endogenous cellular TRAC activity. Use of this inhibitor
has uncovered a differential function of TRACs on negative versus positive thyroid hormone …