Phagocytic docking without shocking
J Savill - Nature, 1998 - nature.com
J Savill
Nature, 1998•nature.comApoptosis, or programmed cell death, has been a vibrant research topic for some time. But
there has been little study of the process by which dying cells are cleared away—that is, how
they are recognized, engulfed and degraded by phagocytes. Two studies (one involving the
nematode Caenorhabditis elegans, the other human cells) now implicate the CED-5
molecule in the cytoskeletal reorganization necessary for the engulfing cell to do its job, and
the CD14 protein in the process of tethering apoptotic cells to phagocytes.
there has been little study of the process by which dying cells are cleared away—that is, how
they are recognized, engulfed and degraded by phagocytes. Two studies (one involving the
nematode Caenorhabditis elegans, the other human cells) now implicate the CED-5
molecule in the cytoskeletal reorganization necessary for the engulfing cell to do its job, and
the CD14 protein in the process of tethering apoptotic cells to phagocytes.
Apoptosis, or programmed cell death, has been a vibrant research topic for some time. But there has been little study of the process by which dying cells are cleared away — that is, how they are recognized, engulfed and degraded by phagocytes. Two studies (one involving the nematodeCaenorhabditis elegans, the other human cells) now implicate the CED-5 molecule in the cytoskeletal reorganization necessary for the engulfing cell to do its job, and the CD14 protein in the process of tethering apoptotic cells to phagocytes.
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