Getting knotted: a model for the structure and activation of Spätzle
K Mizuguchi, JS Parker, TL Blundell, NJ Gay - Trends in biochemical …, 1998 - cell.com
K Mizuguchi, JS Parker, TL Blundell, NJ Gay
Trends in biochemical sciences, 1998•cell.comSequence analyses show that Spätzle, the Drosophila melanogaster Toll-receptor ligand,
shows striking similarity to nerve growth factor and coagulogen. Comparative modelling
suggests that Spätzle adopts a cystine-knot fold and forms a dimer that contains a single,
intermolecular disulphide bridge. Proteolytically cleaved Spätzle could therefore dimerize
and activate the Toll receptor by inducing receptor dimerization.
shows striking similarity to nerve growth factor and coagulogen. Comparative modelling
suggests that Spätzle adopts a cystine-knot fold and forms a dimer that contains a single,
intermolecular disulphide bridge. Proteolytically cleaved Spätzle could therefore dimerize
and activate the Toll receptor by inducing receptor dimerization.
Abstract
Sequence analyses show that Spätzle, the Drosophila melanogaster Toll-receptor ligand, shows striking similarity to nerve growth factor and coagulogen. Comparative modelling suggests that Spätzle adopts a cystine-knot fold and forms a dimer that contains a single, intermolecular disulphide bridge. Proteolytically cleaved Spätzle could therefore dimerize and activate the Toll receptor by inducing receptor dimerization.
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