Metabolism and mechanism of action of 5-fluorouracil
This is a review on the mechanism of action of FUra. Three main areas are addressed:
metabolism, RNA-directed actions of FUra, and DNA-directed actions of FUra. Key words for
bibliographic purposes: metabolism, RNA, rRNA, mRNA, tRNA, DNA primase, DNA,
thylidylate synthetase, uracil N-glycosylase, FUra, FUrd, FdUrd, FdUMP, RNA splicing, 5, 10-
methylene tetrahydrofolate, FUTP.
metabolism, RNA-directed actions of FUra, and DNA-directed actions of FUra. Key words for
bibliographic purposes: metabolism, RNA, rRNA, mRNA, tRNA, DNA primase, DNA,
thylidylate synthetase, uracil N-glycosylase, FUra, FUrd, FdUrd, FdUMP, RNA splicing, 5, 10-
methylene tetrahydrofolate, FUTP.
Abstract
This is a review on the mechanism of action of FUra. Three main areas are addressed: metabolism,RNA-directed actions of FUra, and DNA-directed actions of FUra. Key words for bibliographic purposes: metabolism, RNA, rRNA, mRNA, tRNA, DNA primase, DNA, thylidylate synthetase, uracil N-glycosylase, FUra, FUrd, FdUrd, FdUMP, RNA splicing, 5,10-methylene tetrahydrofolate, FUTP.
Elsevier