[HTML][HTML] NHE-RF, a regulatory cofactor for Na+-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins
A Murthy, C Gonzalez-Agosti, E Cordero… - Journal of Biological …, 1998 - ASBMB
We have identified the human homologue of a regulatory cofactor of Na+-H+ exchanger
(NHE-RF) as a novel interactor for merlin, the neurofibromatosis 2 tumor suppressor protein.
NHE-RF mediates protein kinase A regulation of Na+-H+ exchanger NHE3 to which it is
thought to bind via one of its two PDZ domains. The carboxyl-terminal region of NHE-RF,
downstream of the PDZ domains, interacts with the amino-terminal protein 4.1 domain-
containing segment of merlin in yeast two-hybrid assays. This interaction also occurs in …
(NHE-RF) as a novel interactor for merlin, the neurofibromatosis 2 tumor suppressor protein.
NHE-RF mediates protein kinase A regulation of Na+-H+ exchanger NHE3 to which it is
thought to bind via one of its two PDZ domains. The carboxyl-terminal region of NHE-RF,
downstream of the PDZ domains, interacts with the amino-terminal protein 4.1 domain-
containing segment of merlin in yeast two-hybrid assays. This interaction also occurs in …