Functional and molecular aspects of renal prostaglandin receptors.
MD Breyer, HR Jacobson… - Journal of the American …, 1996 - journals.lww.com
The diverse intrarenal effects of the prostaglandins (PG) are mediated by distinct guanine
nucleotide regulatory protein (G-protein)-coupled receptors. The cDNA for these receptors
have been cloned, their signal transduction mechanisms determined, and their intrarenal
distribution mapped. PGE2, the major intrarenal prostaglandin, interacts with at least three
distinct E-prostanoid (EP) receptors that are highly expressed in specific regions of the
kidney. Each EP receptor not only selectively binds PGE2, but also preferentially couples to …
nucleotide regulatory protein (G-protein)-coupled receptors. The cDNA for these receptors
have been cloned, their signal transduction mechanisms determined, and their intrarenal
distribution mapped. PGE2, the major intrarenal prostaglandin, interacts with at least three
distinct E-prostanoid (EP) receptors that are highly expressed in specific regions of the
kidney. Each EP receptor not only selectively binds PGE2, but also preferentially couples to …