[HTML][HTML] A novel protease inhibitor of the α2-macroglobulin family expressed in the human epidermis
MF Galliano, E Toulza, H Gallinaro, N Jonca… - Journal of biological …, 2006 - ASBMB
In the course of a large scale analysis of late-expressed genes in the human epidermis, we
identified a new member of the α 2-macroglobulin (α2M) protease inhibitor family, A2ML1
(for α 2-macroglobulin-like 1). Like A2M and PZP, A2ML1 is located on chromosome 12p13.
31. A2ML1 encodes a protein of 1454 amino acids, which fits the characteristics of α2Ms: 1)
strong conservation in amino acid sequence including most of cysteine positions with α2M;
2) a putative central bait domain; 3) a typical thiol ester sequence. Northern blot and reverse …
identified a new member of the α 2-macroglobulin (α2M) protease inhibitor family, A2ML1
(for α 2-macroglobulin-like 1). Like A2M and PZP, A2ML1 is located on chromosome 12p13.
31. A2ML1 encodes a protein of 1454 amino acids, which fits the characteristics of α2Ms: 1)
strong conservation in amino acid sequence including most of cysteine positions with α2M;
2) a putative central bait domain; 3) a typical thiol ester sequence. Northern blot and reverse …