P63 in pulmonary epithelium, pulmonary squamous neoplasms, and other pulmonary tumors

BY Wang, J Gil, D Kaufman, L Gan, DS Kohtz… - Human pathology, 2002 - Elsevier
p63 is a p53-homologous nuclear protein that appears to play a crucial role in regulation of
stem cell commitment in squamous and other epithelia. In this study, p63 expression was
examined in benign lung and in neoplasms of pulmonary origin. Eighty sections from
routinely fixed and processed archival bronchoscopic biopsy or lobectomy specimens were
pretreated with citric acid (pH 6.0) for antigen retrieval, then incubated overnight with anti-
p63 monoclonal antibody 4A4. Slides were stained using a streptavidin-biotin kit and …