Induction of endothelial cell tissue factor activity by sera from patients with antiphospholipid syndrome: a possible mechanism of thrombosis
DW Branch, GM Rodgers - American journal of obstetrics and gynecology, 1993 - Elsevier
Objective: The hypothesis of our study is that antiphospholipid antibodies predispose to
thrombosis by inducing endothelial cell tissue factor expression. Study Design: Monolayers
of cultured human umbilical vein endothelial cells were incubated for 8 hours in a medium
containing 20% serum obtained either from patients with antiphospholipid antibodies (n=
11) or normal subjects (n= 8). Similar incubations were performed with immunoglobulin G
fractions from either patients with antiphospholipid antibodies (n= 3) or normal subjects (n …
thrombosis by inducing endothelial cell tissue factor expression. Study Design: Monolayers
of cultured human umbilical vein endothelial cells were incubated for 8 hours in a medium
containing 20% serum obtained either from patients with antiphospholipid antibodies (n=
11) or normal subjects (n= 8). Similar incubations were performed with immunoglobulin G
fractions from either patients with antiphospholipid antibodies (n= 3) or normal subjects (n …